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Issue 1, 2016
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Antioxidant activity of phytoestrogen type isoflavones in biomimetic environments

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Abstract

The work aims to simulate in vitro the antioxidant activity of four phytoestrogen type isoflavones, whose effects are closer to those of estradiol (daidzein, formononetin, genistein, biochanin A) in biomimetic environments (in lecithin lipidic bi-layers and on silver nanoparticles), using the chemiluminescent system luminol–hydrogen peroxide, in phosphate buffer, pH 7.4. The contribution of a carrier protein, human serum albumin (HSA), to the antioxidant activity of these isoflavones has also been investigated. The rate of the fluorescence quenching of HSA by isoflavone as well as the binding constant of isoflavone to HSA, in both lecithin lipidic bi-layers and on silver nanoparticles, has also been investigated by fluorescence spectroscopy. The results are discussed with relevance to the oxidative stress process.

Graphical abstract: Antioxidant activity of phytoestrogen type isoflavones in biomimetic environments

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Publication details

The article was received on 23 Jun 2015, accepted on 31 Oct 2015 and first published on 19 Nov 2015


Article type: Paper
DOI: 10.1039/C5NJ01568E
Citation: New J. Chem., 2016,40, 606-612
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    Antioxidant activity of phytoestrogen type isoflavones in biomimetic environments

    M. Voicescu, P. Hellwig and A. Meghea, New J. Chem., 2016, 40, 606
    DOI: 10.1039/C5NJ01568E

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