Issue 2, 2015

Sensitive ctDNA detection by a novel zinc(ii) complex with two-photon absorption based on electrochemiluminescence

Abstract

Here we report that a novel zinc(II) complex with an intramolecular ‘push–pull’ structure was synthesized and fully characterized. For the zinc(II) complex, the photoluminescence (PL) emission wavelength is at 460 nm and the excitation wavelength is at 380 nm. The two-photon absorption cross-section (σ) of the zinc(II) complex reached 140 GM (1 GM = 1 × 10−50 cm4 s photon−1). An electrochemiluminescence (ECL) sensor could be built with a glass carbon disk electrode (GCE, Φ 4 mm) modified with the zinc(II) complex, and this exhibited an enhanced ECL intensity, good biocompatibility and long-term stability to detect ctDNA. Meanwhile, the reliability of the extracted signal was demonstrated in solutions of different pH values.

Graphical abstract: Sensitive ctDNA detection by a novel zinc(ii) complex with two-photon absorption based on electrochemiluminescence

Supplementary files

Article information

Article type
Paper
Submitted
04 Oct 2014
Accepted
02 Dec 2014
First published
15 Dec 2014

New J. Chem., 2015,39, 1404-1409

Sensitive ctDNA detection by a novel zinc(II) complex with two-photon absorption based on electrochemiluminescence

J. Yang, B. Liu, J. Wu, S. Zhang, B. Jin and Y. Tian, New J. Chem., 2015, 39, 1404 DOI: 10.1039/C4NJ01727G

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