Issue 6, 2013

Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

Abstract

A mild and efficient method has been developed for the direct dehydrogenative alkylation of unprotonated pyridine derivatives. The avoidance of using acids and transition-metals makes this protocol “greener” and more practical for the synthesis of substituted pyridines.

Graphical abstract: Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

Supplementary files

Article information

Article type
Letter
Submitted
23 Jan 2013
Accepted
03 Apr 2013
First published
03 Apr 2013

New J. Chem., 2013,37, 1704-1706

Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

X. Li, H. Wang and Z. Shi, New J. Chem., 2013, 37, 1704 DOI: 10.1039/C3NJ00095H

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