Issue 11, 2012
From the journal:

New Journal of Chemistry

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs†

Boris Redko,ab   Amnon Albeckb  and  Gary Gellerman*a  

* Corresponding authors

a Department of Biological Chemistry, Ariel University Center of Samaria, Ariel 40700, Israel
E-mail: garyg@ariel.ac.il
Fax: +972 3 9066634
Tel: +972 3 9371442

b The Julius Spokojny Bioorganic Chemistry Laboratory, Department of Chemistry, Bar-Ilan University, Ramat Gan 52900, Israel
E-mail: amnon.albeck@biu.ac.il
Fax: +972 3 7384053
Tel: +972 3 5318862

Abstract

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

Graphical abstract: Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

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Article information

DOI
https://doi.org/10.1039/C2NJ40567A
Article type
Letter
Submitted
04 Jul 2012
Accepted
29 Aug 2012
First published
31 Aug 2012

New J. Chem., 2012,36, 2188-2191

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Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

B. Redko, A. Albeck and G. Gellerman, New J. Chem., 2012, 36, 2188 DOI: 10.1039/C2NJ40567A

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