Issue 9, 2010
From the journal:

New Journal of Chemistry

Magnesium dependent complexation of tri-anionic calix[4]arenedetergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1†

Laurent F. A. Nault,a   Celine Girardot,a   Antoine Leydier,a   Anthony W. Coleman,*a   Thomas Perrotton,b   Sandrine Magnardb  and  Helene Baubichon-Cortay*b  

* Corresponding authors

a Laboratoire de Multimateriaux et Interfaces, UMR 5615 CNRS-Université de Lyon, 43 bvd 11 novembre 1918, 69622 Villeurbanne, France
E-mail: antony.coleman@adm.univ-lyon1.fr
Tel: +33 472431027

b Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-Université de Lyon, IFR 128 Biosciences, 7 passage du Vercors, 69367 Lyon cedex 07, France
E-mail: h.cortay@ibcp.fr
Fax: +33 472722604
Tel: +33 472722691

Abstract

The tri-carboxylatomethylene-mono-alkoxy calix[4]arenes have been shown by fluorescence spectroscopy to bind to the NBD1 domain of MRP1 protein in a magnesium dependent manner. The observed associations constants are of the same order as that observed for ATP–Mg, the natural substrate for this protein.

Graphical abstract: Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1

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Article information

DOI
https://doi.org/10.1039/C0NJ00323A
Article type
Letter
Submitted
28 Apr 2010
Accepted
26 May 2010
First published
22 Jun 2010

New J. Chem., 2010,34, 1812-1815

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Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1

L. F. A. Nault, C. Girardot, A. Leydier, A. W. Coleman, T. Perrotton, S. Magnard and H. Baubichon-Cortay, New J. Chem., 2010, 34, 1812 DOI: 10.1039/C0NJ00323A

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