Issue 9, 2010
From the journal:

New Journal of Chemistry

Asymmetric organocatalytic Michael addition of azlactones to cis-1,2-bis(phenylsulfonyl)ethene. A simple entry to quaternary α-amino acids†‡

Natalia Bravo,a   Andrea-Nekane R. Alba,a   Guillem Valero,a   Xavier Companyó,a   Albert Moyano*a  and  Ramon Rios*ab  

* Corresponding authors

a Universitat de Barcelona, Departament of Organic Chemistry, c/Martí iFranqués 1-11, 08028 Barcelona, Spain
E-mail: rios.ramon@icrea.cat, amoyano@ub.edu
Fax: +34 933397878

b ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain

Abstract

Azlactones react with 1,2-bis(phenylsulfonyl)ethene under catalysis by simple chiral thioureas, affording α,α-disubstituted α-amino acid derivatives in good yields and in moderate to good enantioselectivities.

Graphical abstract: Asymmetric organocatalytic Michael addition of azlactones to cis-1,2-bis(phenylsulfonyl)ethene. A simple entry to quaternary α-amino acids

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Article information

DOI
https://doi.org/10.1039/C0NJ00321B
Article type
Letter
Submitted
27 Apr 2010
Accepted
01 Jun 2010
First published
22 Jun 2010

New J. Chem., 2010,34, 1816-1820

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Asymmetric organocatalytic Michael addition of azlactones to cis-1,2-bis(phenylsulfonyl)ethene. A simple entry to quaternary α-amino acids

N. Bravo, A. R. Alba, G. Valero, X. Companyó, A. Moyano and R. Rios, New J. Chem., 2010, 34, 1816 DOI: 10.1039/C0NJ00321B

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