Issue 5, 2009
From the journal:

New Journal of Chemistry

A chemo-enzymatic synthesis of chiral secondary alcohols bearing sulfur-containing functionality†

Qihui Chen,a   Ke Wanga  and  Chengye Yuan*a  

* Corresponding authors

a State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Feng-Lin Lu, China
E-mail: yuancy@mail.sioc.ac.cn
Fax: +86 21-5492-5379

Abstract

A facile method for the preparation of chiral secondary alcohols bearing a sulfur-containing functionality using a chemo-enzymatic approach is described, with the aid of baker’s yeast and Candida Antarctica lipase B. A complete set of four stereoisomers of two substituted phenylsulfinylpropan-2-ols were synthesized from β-sulfinyl ketones with excellent enantioselectivity for the first time.

Graphical abstract: A chemo-enzymatic synthesis of chiral secondary alcohols bearing sulfur-containing functionality

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Article information

DOI
https://doi.org/10.1039/B820192G
Article type
Letter
Submitted
12 Nov 2008
Accepted
17 Dec 2008
First published
12 Jan 2009

New J. Chem., 2009,33, 972-975

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A chemo-enzymatic synthesis of chiral secondary alcohols bearing sulfur-containing functionality

Q. Chen, K. Wang and C. Yuan, New J. Chem., 2009, 33, 972 DOI: 10.1039/B820192G

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