Issue 5, 2007

Luminescent assays for ketones and aldehydes employing catalytic signal amplification

Abstract

Herein we report the first use of transition metal catalytic signal enhancement for the analysis of small organic analytes. Two assays using Sonogashira and Suzuki cross-couplings have been used in the detection of ketones and aldehydes produce highly luminescent markers. The latter analysis utilizing the Suzuki coupling demonstrates the first use of peroxyoxalate initiated chemiluminescence in a sensing application. Chemiluminescent measurement revealed much higher sensitivity than fluorescence.

Graphical abstract: Luminescent assays for ketones and aldehydes employing catalytic signal amplification

Supplementary files

Article information

Article type
Paper
Submitted
16 Nov 2006
Accepted
15 Jan 2007
First published
21 Feb 2007

New J. Chem., 2007,31, 729-735

Luminescent assays for ketones and aldehydes employing catalytic signal amplification

R. J. T. Houk and E. V. Anslyn, New J. Chem., 2007, 31, 729 DOI: 10.1039/B616765A

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