Highly selective O-phosphitylation of amino alcohols using PIIIreagents containing 4-nitro and 2,4-dinitro aryloxy leaving groups

Abstract

A method for direct highly O-selective phosphitylation of amino alcohols by reagents containing a 4-nitrophenoxy or 2,4 dinitrophenoxy leaving group has been developed. This method provides mild reaction conditions to access O-phosphitylated amino alcohols. The flexibility of the synthesis is exemplified by the models of simple amino alcohols and of nucleosides containing unprotected NH₂ groups.