Jump to main content
Jump to site search

Issue 5, 2002
Previous Article Next Article

Efficient synthesis of novel macrocyclic tetraamide compounds: a unique reaction process involving both self-assembling and folding of intermediates

Author affiliations

Abstract

A macrocycle having two isobutenyl and four amide moieties was successfully formed via two kinds of acyclic intermediates. These key intermediates possess the ability to self-organize due to intra- or intermolecular hydrogen-bonding interactions. In both intermediates, preorganized structures were favorably subject to nucleophilic attack at the carbonyl group by a terminal amino group, and preorganization made it possible to form the macrocycle under mild conditions.

Back to tab navigation

Publication details

The article was received on 02 Jan 2002, accepted on 28 Feb 2002 and first published on 15 Apr 2002


Article type: Letter
DOI: 10.1039/B200177M
Citation: New J. Chem., 2002,26, 503-507
  •   Request permissions

    Efficient synthesis of novel macrocyclic tetraamide compounds: a unique reaction process involving both self-assembling and folding of intermediates

    M. Numata, K. Hiratani, Y. Nagawa, H. Houjou, S. Masubuchi and S. Akabori, New J. Chem., 2002, 26, 503
    DOI: 10.1039/B200177M

Search articles by author

Spotlight

Advertisements