Jump to main content
Jump to site search

Issue 8, 2013
Previous Article Next Article

Fluorescent silver(I) and gold(I)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights

Author affiliations

Abstract

Silver(I) and gold(I)–N-heterocyclic carbene (NHC) complexes bearing a fluorescent anthracenyl ligand were examined for cytotoxicity in normal and tumor cells. The silver(I) complex exhibits greater cytotoxicity in tumor cells compared with normal cells. Notably, in cell extracts, this complex determines a more pronounced inhibition of thioredoxin reductase (TrxR), but it is ineffective towards glutathione reductase (GR). Both gold and silver complexes lead to oxidation of the thioredoxin system, the silver(I) derivative being particularly effective. In addition, the dimerization of peroxiredoxin 3 (Prx3) was also observed, demonstrating the ability of these compounds to reach the mitochondrial target. The fluorescence microscopy visualization of the subcellular distribution of the complexes shows a larger diffusion of these molecules in tumor cells with respect to normal cells.

Graphical abstract: Fluorescent silver(i) and gold(i)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Dec 2012, accepted on 16 Apr 2013 and first published on 17 Apr 2013


Article type: Paper
DOI: 10.1039/C3MT20260G
Citation: Metallomics, 2013,5, 1006-1015
  •   Request permissions

    Fluorescent silver(I) and gold(I)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights

    A. Citta, E. Schuh, F. Mohr, A. Folda, M. L. Massimino, A. Bindoli, A. Casini and M. P. Rigobello, Metallomics, 2013, 5, 1006
    DOI: 10.1039/C3MT20260G

Search articles by author

Spotlight

Advertisements