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Issue 1, 2017
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Adaptive mechanisms of resistance to anti-neoplastic agents

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Intrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses.

Graphical abstract: Adaptive mechanisms of resistance to anti-neoplastic agents

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Publication details

The article was received on 15 Jul 2016, accepted on 19 Oct 2016 and first published on 21 Oct 2016

Article type: Review Article
DOI: 10.1039/C6MD00394J
Citation: Med. Chem. Commun., 2017,8, 53-66
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    Adaptive mechanisms of resistance to anti-neoplastic agents

    B. I. Ferreira, M. K. Lie, A. S. T. Engelsen, S. Machado, W. Link and J. B. Lorens, Med. Chem. Commun., 2017, 8, 53
    DOI: 10.1039/C6MD00394J

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