SCHEDULED MAINTENANCE
The activity screening of a library of aurones led to the identification of sub-micromolar human neutrophil elastase (HNE) inhibitors. The activity is rationalized by a C-shape conformation that allows tight binding to HNE S1 and S2 pockets.
S. D. Lucas, M. P. Carrasco, L. M. Gonçalves, R. Moreira and R. C. Guedes, Med. Chem. Commun., 2015, 6, 1508 DOI: 10.1039/C5MD00164A
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