Issue 5, 2014

Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: their evaluation as novel and potential insulin secretagogues

Abstract

A series of N-(alkyl/aryl/heteroaryl)-1-nitro-10H-phenoxazine-3-sulfonamides was designed, synthesized and evaluated for its hypoglycemic, hyperglycemic and oral anti-diabetic activities. These compounds were prepared via the construction of a phenoxazine ring containing nitro and sulfonic acid groups in a single step followed by further transformations. One of these compounds exhibited promising anti-diabetic activities comparable to glibenclamide and increased serum insulin levels indicating its potential as a novel insulin secretagogue.

Graphical abstract: Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: their evaluation as novel and potential insulin secretagogues

Supplementary files

Article information

Article type
Concise Article
Submitted
09 Dec 2013
Accepted
23 Jan 2014
First published
24 Jan 2014

Med. Chem. Commun., 2014,5, 587-592

Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: their evaluation as novel and potential insulin secretagogues

S. V. Reddy, G. M. Rao, B. V. Kumar, K. N. Reddy, K. Sravya, P. Goverdhan, V. Rathore, G. S. Deora and M. Pal, Med. Chem. Commun., 2014, 5, 587 DOI: 10.1039/C3MD00377A

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