Issue 2, 2014

Synthesis of metergoline analogues and their evaluation as antiplasmodial agents

Abstract

A series of compounds based on metergoline were synthesized and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 strain of the malaria parasite Plasmodium falciparum. These compounds were also screened for their cytotoxicity towards a mammalian cell line. Some of the compounds exhibited superior antiplasmodial activity with a good selectivity index relative to metergoline.

Graphical abstract: Synthesis of metergoline analogues and their evaluation as antiplasmodial agents

Supplementary files

Article information

Article type
Concise Article
Submitted
16 Oct 2013
Accepted
07 Dec 2013
First published
24 Dec 2013

Med. Chem. Commun., 2014,5, 165-170

Author version available

Synthesis of metergoline analogues and their evaluation as antiplasmodial agents

K. Singh, G. Kaur, F. Mjambili, P. J. Smith and K. Chibale, Med. Chem. Commun., 2014, 5, 165 DOI: 10.1039/C3MD00310H

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