Issue 12, 2012

Pharmacokinetics of bendamustine in the central nervous system: chemoinformatic screening followed by validation in a murine model

Abstract

Bendamustine is a novel bifunctional chemotherapeutic agent with activity against multiple cancers. There has been no definitive data on its capacity to penetrate the central nervous system. Our chemoinformatic screening predicted excellent CNS penetration, which was validated by in vivo pharmacokinetic analysis in mice. Bendamustine has 35% CNS penetration in our mouse model. Bendamustine should be further evaluated for use in treatment of primary and secondary CNS tumors.

Graphical abstract: Pharmacokinetics of bendamustine in the central nervous system: chemoinformatic screening followed by validation in a murine model

Article information

Article type
Concise Article
Submitted
07 Aug 2012
Accepted
03 Oct 2012
First published
04 Oct 2012

Med. Chem. Commun., 2012,3, 1526-1530

Pharmacokinetics of bendamustine in the central nervous system: chemoinformatic screening followed by validation in a murine model

Z. Li, T. Caulfield, Y. Qiu, J. A. Copland and H. W. Tun, Med. Chem. Commun., 2012, 3, 1526 DOI: 10.1039/C2MD20233F

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