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Issue 10, 2012
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Rational design of small modified peptides as ACE inhibitors

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Abstract

Computer-assisted techniques and the strategy of combining chemical substructures were used to derive small modified peptides as potent angiotensin-converting enzyme (ACE) inhibitors. In addition to high potency, some of the predicted compounds are also shown to exhibit satisfactory pharmacokinetic parameters.

Graphical abstract: Rational design of small modified peptides as ACE inhibitors

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Publication details

The article was received on 25 Apr 2012, accepted on 29 Aug 2012 and first published on 31 Aug 2012


Article type: Concise Article
DOI: 10.1039/C2MD20214J
Citation: Med. Chem. Commun., 2012,3, 1290-1293
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    Rational design of small modified peptides as ACE inhibitors

    D. G. Silva, M. P. Freitas, E. F. F. da Cunha, T. C. Ramalho and C. A. Nunes, Med. Chem. Commun., 2012, 3, 1290
    DOI: 10.1039/C2MD20214J

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