Issue 7, 2012
From the journal:

MedChemComm

Deciphering intracellular targets of organochalcogen based redox catalysts†

Thomas Schneider,ab   Yazh Muthukumar,b   Bettina Hinkelmann,b   Raimo Franke,b   Mandy Döring,a   Claus Jacoba  and  Florenz Sasse*b  

* Corresponding authors

a Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany

b Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany
E-mail: florenz.sasse@helmholtz-hzi.de
Fax: +49 531-6181-3499

Abstract

Traditionally, the activity of organochalcogen based redox catalysts in cancer cells has been associated with the increase of ROS levels. Using a phenotype guided approach we were able to identify tubulin and actin as targets of tellurium containing redox catalysts. This is the first detection of a defined intracellular target of such compounds.

Graphical abstract: Deciphering intracellular targets of organochalcogen based redox catalysts

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Article information

DOI
https://doi.org/10.1039/C2MD20049J
Article type
Concise Article
Submitted
20 Feb 2012
Accepted
18 May 2012
First published
22 May 2012

Med. Chem. Commun., 2012,3, 784-787

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Deciphering intracellular targets of organochalcogen based redox catalysts

T. Schneider, Y. Muthukumar, B. Hinkelmann, R. Franke, M. Döring, C. Jacob and F. Sasse, Med. Chem. Commun., 2012, 3, 784 DOI: 10.1039/C2MD20049J

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