Issue 3, 2012

New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

Abstract

The research into selective ligands of misfolded protein plaques in Alzheimer's disease and in transmissible spongiform encephalopathies led to compound 3, based on the Congo Red framework and bearing two trifluoromethoxy groups. Histochemical experiments on human brain tissues showed intense fluorescent staining of fibrillary deposits in both pathologies.

Graphical abstract: New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

Article information

Article type
Concise Article
Submitted
07 Oct 2011
Accepted
25 Nov 2011
First published
30 Nov 2011

Med. Chem. Commun., 2012,3, 357-361

New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

C. Mustazza, M. Sbriccoli, A. Borioni, R. Ferretti and M. R. Del Giudice, Med. Chem. Commun., 2012, 3, 357 DOI: 10.1039/C2MD00254J

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