A new route to indolesvia in situdesilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents

Ali Nakhi; Bagineni Prasad; Uppender Reddy; Raja Mohan Rao; Sandhya Sandra; Ravikumar Kapavarapu; D. Rambabu; G. Rama Krishna; C. Malla Reddy; Kishore Ravada; Parimal Misra; Javed Iqbal; Manojit Pal

doi:10.1039/C1MD00148E

A new route to indolesvia in situdesilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents†

Ali Nakhi,^a Bagineni Prasad,^a Uppender Reddy,^a Raja Mohan Rao,^a Sandhya Sandra,^a Ravikumar Kapavarapu,^a D. Rambabu,^a G. Rama Krishna,^b C. Malla Reddy,^b Kishore Ravada,^c Parimal Misra,^a Javed Iqbal*^a and Manojit Pal*^a

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* Corresponding authors

^a Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India
E-mail: manojitpal@rediffmail.com

^b Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal, India

^c School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, India

Abstract

A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of indoles containing an o-(RSO₂NH)C₆H₄ group at the C-2 position. The methodology provided novel indoles as inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutasein vitro representing the first example of chorismate mutase inhibition by a heteroarene based small molecule.

MedChemComm

A new route to indolesvia in situdesilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents†

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A new route to indolesvia in situdesilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents

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