Issue 11, 2011
From the journal:

MedChemComm

Solution-phase synthesis of chiral O-acyl isodipeptides†

Mirna El Khatib,a   Lilibeth Jauregui,a   Srinivasa R. Tala,a   Levan Khelashvilia  and  Alan R. Katritzky*ab  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA
E-mail: katritzky@chem.ufl.edu

b Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract

O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74–91%.

Graphical abstract: Solution-phase synthesis of chiral O-acyl isodipeptides

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Article information

DOI
https://doi.org/10.1039/C1MD00130B
Article type
Concise Article
Submitted
19 May 2011
Accepted
16 Aug 2011
First published
14 Sep 2011

Med. Chem. Commun., 2011,2, 1087-1092

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Solution-phase synthesis of chiral O-acyl isodipeptides

M. El Khatib, L. Jauregui, S. R. Tala, L. Khelashvili and A. R. Katritzky, Med. Chem. Commun., 2011, 2, 1087 DOI: 10.1039/C1MD00130B

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