Issue 4, 2011

Structure and antimicrobial properties of multivalent short peptides

Abstract

The emergence of multidrug-resistant (MDR) strains continues to threaten human health. Along with many efforts directed towards the development of antimicrobial peptides (AMPs) as potential antibiotics, we have designed and tested several series of multivalent AMPs in comparison with the natural AMP, indolicidin. Constructs include multivalent displays with different sequences, repeats and scaffolds, including dendrimers, brush-like structures and polymeric displays constructed by linking various peptides to polymaleic anhydride (PMA). A branched tetramer of dipeptides (RW)4D demonstrates the highest level of effectiveness among the constructs of this study. The results also show that under extended exposure to sublethal doses of (RW)4D and indolicidin over a 400 generations period, MDR strains elicit much lower levels of resistance than to traditional antibiotics or disinfectants such as ciprofloxacin, vancomycin, chlorhexidine and gentamicin.

Graphical abstract: Structure and antimicrobial properties of multivalent short peptides

Supplementary files

Article information

Article type
Concise Article
Submitted
03 Dec 2010
Accepted
18 Jan 2011
First published
28 Feb 2011

Med. Chem. Commun., 2011,2, 308-314

Structure and antimicrobial properties of multivalent short peptides

A. W. Young, Z. Liu, C. Zhou, F. Totsingan, N. Jiwrajka, Z. Shi and N. R. Kallenbach, Med. Chem. Commun., 2011, 2, 308 DOI: 10.1039/C0MD00247J

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