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Issue 10, 2015
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Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

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Abstract

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel β-sheet scaffold (β-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained β-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.

Graphical abstract: Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

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Publication details

The article was received on 06 May 2015, accepted on 17 Jun 2015 and first published on 29 Jun 2015


Article type: Communication
DOI: 10.1039/C5MB00316D
Author version available: Download Author version (PDF)
Citation: Mol. BioSyst., 2015,11, 2713-2716
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    Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

    H. Tsutsumi, K. Nakano and H. Mihara, Mol. BioSyst., 2015, 11, 2713
    DOI: 10.1039/C5MB00316D

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