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Issue 6, 2014
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How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

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Abstract

Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme.

Graphical abstract: How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

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Publication details

The article was received on 03 Feb 2014, accepted on 19 Mar 2014 and first published on 19 Mar 2014


Article type: Paper
DOI: 10.1039/C4MB00141A
Citation: Mol. BioSyst., 2014,10, 1490-1495
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    How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

    T. G. Karabencheva, C. C. Lee, G. W. Black, R. Donev and C. Z. Christov, Mol. BioSyst., 2014, 10, 1490
    DOI: 10.1039/C4MB00141A

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