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Issue 8, 2013
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Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles

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Abstract

The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated with multivalency, which amplifies the electrostatic attraction. This strategy may lead to the development of novel molecular probes for detecting highly curved membrane bilayers.

Graphical abstract: Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles

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Publication details

The article was received on 16 Mar 2013, accepted on 08 May 2013 and first published on 09 May 2013


Article type: Communication
DOI: 10.1039/C3MB70109C
Citation: Mol. BioSyst., 2013,9, 2005-2009
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    Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles

    J. P. Saludes, L. A. Morton, S. K. Coulup, Z. Fiorini, B. M. Cook, L. Beninson, E. R. Chapman, M. Fleshner and H. Yin, Mol. BioSyst., 2013, 9, 2005
    DOI: 10.1039/C3MB70109C

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