Issue 4, 2013
From the journal:

Molecular BioSystems

Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging†

Hang-Suk Chun,‡a   Jong Hyun Jeon,‡a   Haushabhau S. Pagire,ab   Jae Hong Lee,a   Hee-Chung Chung,a   Myoung Joo Park,a   Ju-Hoon So,a   Jae-Ho Ryu,c   Cheol-Hee Kim,c   Jin Hee Ahn*ab  and  Myung Ae Bae*a  

* Corresponding authors

a Bioorganic Science Division, Korea Research Institute of Chemical Technology, Jang-Dong 100, Yuseong, Daejeon, South Korea
E-mail: mbae@krict.re.kr, jhahn@krict.re.kr
Fax: +82 42 860 7459
Tel: +82 42 860 7084

b Medicinal and Pharmaceutical Chemistry Major, University of Science and Technology, 113 Gwahango, Yuseong, Daejeon, South Korea

c Department of Biology, Chungnam National University, Daejeon 305-764, South Korea

Abstract

We have developed LipidGreen2, a second generation small molecule probe for lipid imaging. LipidGreen2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish. We also demonstrate the application of LipidGreen2 for detecting fatty liver.

Graphical abstract: Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging

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Article information

DOI
https://doi.org/10.1039/C3MB70022D
Article type
Communication
Submitted
03 Oct 2012
Accepted
31 Jan 2013
First published
15 Feb 2013

Mol. BioSyst., 2013,9, 630-633

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Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging

H. Chun, J. H. Jeon, H. S. Pagire, J. H. Lee, H. Chung, M. J. Park, J. So, J. Ryu, C. Kim, J. H. Ahn and M. A. Bae, Mol. BioSyst., 2013, 9, 630 DOI: 10.1039/C3MB70022D

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