Issue 5, 2010
From the journal:

Molecular BioSystems

Size control of lipid-based drugcarrier by drug loading†

Tatsuya Murakami,*ab   Kunihiro Tsuchida,c   Mitsuru Hashidaad  and  Hiroshi Imahori*ae  

* Corresponding authors

a Institute for Integrated Cell-Material Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: murakami@icems.kyoto-u.ac.jp
Fax: +81-75-753-4575
Tel: +81-75-753-4545

b PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

c Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan
E-mail: tsuchida@fujita-hu.ac.jp
Fax: +81-562-93-5791
Tel: +81-562-93-9384

d Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: hashidam@pharm.kyoto-u.ac.jp
Fax: +81-75-753-4575
Tel: +81-75-753-4525

e Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: imahori@scl.kyoto-u.ac.jp
Fax: +81-75-383-2571
Tel: +81-75-383-2566

Abstract

A phospholipid–protein hybrid nanostructure was found to reveal various hydrodynamic diameters dependent on the amount of the drugs incorporated, which could be over 10 times larger than that of the starting nanostructure. This observation was likely related to the thermal stabilization of the nanostructure during incorporation of the drugs by using the increased amount of phospholipids for the preparation. Furthermore, hydrophobicity or molecular weight of drugs is at least needed for size control.

Graphical abstract: Size control of lipid-based drug carrier by drug loading

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Article information

DOI
https://doi.org/10.1039/C001442G
Article type
Communication
Submitted
21 Jan 2010
Accepted
08 Feb 2010
First published
25 Feb 2010

Mol. BioSyst., 2010,6, 789-791

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Size control of lipid-based drug carrier by drug loading

T. Murakami, K. Tsuchida, M. Hashida and H. Imahori, Mol. BioSyst., 2010, 6, 789 DOI: 10.1039/C001442G

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