Issue 8, 2008
From the journal:

Molecular BioSystems

Binding of a dinuclear ruthenium(ii) complex to the TAR region of the HIV-AIDS viral RNA†

Damian P. Buck,a   Caitriona B. Spillane,b   J. Grant Collins*a  and  F. Richard Keene‡*b  

* Corresponding authors

a School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Canberra, Australia
E-mail: g-collins@adfa.edu.au
Fax: +61-2-6268 8002
Tel: +61-2-6268 8077

b School of Pharmacy & Molecular Sciences, James Cook University, Townsville, Australia
E-mail: Richard.Keene@jcu.edu.au
Fax: +61-7-4781 6078
Tel: +61-7-4781 4433

Abstract

Molecular modelling has identified a new RNA conformational feature created by the insertion of bulge residues into duplex regions that may act as a recognition site for small molecule binding, in particular for inert dinuclear ruthenium complexes.

Graphical abstract: Binding of a dinuclear ruthenium(ii) complex to the TAR region of the HIV-AIDS viral RNA

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Article information

DOI
https://doi.org/10.1039/B803216E
Article type
Communication
Submitted
25 Feb 2008
Accepted
21 May 2008
First published
03 Jun 2008

Mol. BioSyst., 2008,4, 851-854

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Binding of a dinuclear ruthenium(II) complex to the TAR region of the HIV-AIDS viral RNA

D. P. Buck, C. B. Spillane, J. G. Collins and F. R. Keene, Mol. BioSyst., 2008, 4, 851 DOI: 10.1039/B803216E

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