Issue 6, 2008
From the journal:

Molecular BioSystems

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues†‡

Irene Kiburu,a   Andrew Shurer,a   Lei Yana  and  Herman O. Sintim*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA
E-mail: hsintim@umd.edu
Fax: +113013149121
Tel: +113014050633

Abstract

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

Graphical abstract: A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

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DOI
https://doi.org/10.1039/B719423D
Article type
Communication
Submitted
03 Jan 2008
Accepted
21 Apr 2008
First published
29 Apr 2008

Mol. BioSyst., 2008,4, 518-520

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A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

I. Kiburu, A. Shurer, L. Yan and H. O. Sintim, Mol. BioSyst., 2008, 4, 518 DOI: 10.1039/B719423D

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