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Issue 9, 2007
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A genome-scale, constraint-based approach to systems biology of human metabolism

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Abstract

The recent sequencing and annotation of the human genome enables a new era in biomedicine that will be based on an interdisciplinary, systemic approach to the elucidation and treatment of human disease. Reconstruction of genome-scale metabolic networks is an important part of this approach since networks represent the integration of diverse biological data such as genome annotations, high-throughput data, and legacy biochemical knowledge. This article will describe Homo sapiens Recon 1, a functionally tested, genome-scale reconstruction of human cellular metabolism, and its capabilities for facilitating the understanding of physiological and disease metabolic states.

Graphical abstract: A genome-scale, constraint-based approach to systems biology of human metabolism

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Publication details

The article was received on 12 Apr 2007, accepted on 21 Jun 2007 and first published on 11 Jul 2007


Article type: Highlight
DOI: 10.1039/B705597H
Citation: Mol. BioSyst., 2007,3, 598-603
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    A genome-scale, constraint-based approach to systems biology of human metabolism

    M. L. Mo, N. Jamshidi and B. Ø. Palsson, Mol. BioSyst., 2007, 3, 598
    DOI: 10.1039/B705597H

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