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Issue 17, 2016
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Customisable 3D printed microfluidics for integrated analysis and optimisation

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Abstract

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.

Graphical abstract: Customisable 3D printed microfluidics for integrated analysis and optimisation

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Publication details

The article was received on 27 Apr 2016, accepted on 18 Jul 2016 and first published on 18 Jul 2016


Article type: Paper
DOI: 10.1039/C6LC00562D
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2016,16, 3362-3373
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    Customisable 3D printed microfluidics for integrated analysis and optimisation

    T. Monaghan, M. J. Harding, R. A. Harris, R. J. Friel and S. D. R. Christie, Lab Chip, 2016, 16, 3362
    DOI: 10.1039/C6LC00562D

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