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Issue 13, 2014
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The equilibrium velocity of spherical particles in rectangular microfluidic channels for size measurement

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Abstract

According to the Segré–Silberberg effect, spherical particles migrate to a lateral equilibrium position in parabolic flow profiles. Here, for the first time, the corresponding equilibrium velocity is studied experimentally for micro particles in channels with rectangular cross section. Micro channels are fabricated in PMMA substrate based on a hot embossing process. To measure individual particle velocities at very high precision, the technique of spatially modulated emission is applied. It is found that the equilibrium velocity is size-dependent and the method offers a new way to measure particle size in microfluidic systems. The method is of particular interest for microfluidic flow cytometry as it delivers an alternative to the scatter signal for cell size determination.

Graphical abstract: The equilibrium velocity of spherical particles in rectangular microfluidic channels for size measurement

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Publication details

The article was received on 02 Dec 2013, accepted on 04 May 2014 and first published on 14 May 2014


Article type: Paper
DOI: 10.1039/C3LC51336J
Citation: Lab Chip, 2014,14, 2319-2326
  • Open access: Creative Commons BY license
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    The equilibrium velocity of spherical particles in rectangular microfluidic channels for size measurement

    C. Sommer, S. Quint, P. Spang, T. Walther and M. Baßler, Lab Chip, 2014, 14, 2319
    DOI: 10.1039/C3LC51336J

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