Issue 4, 2013

Novel flexible Parylene neural probe with 3D sheath structure for enhancing tissue integration

Abstract

A Parylene C neural probe with a three dimensional sheath structure was designed, fabricated, and characterized. Multiple platinum (Pt) electrodes for recording neural signals were fabricated on both inner and outer surfaces of the sheath structure. Thermoforming of Parylene was used to create the three dimensional sheath structures from flat surface micromachined microchannels using solid microwires as molds. Benchtop electrochemical characterization was performed on the thin film Pt electrodes using cyclic voltammetry and electrochemical impedance spectroscopy and showed that electrodes possessed low impedances suitable for neuronal recordings. A procedure for implantation of the neural probe was developed and successfully demonstrated in vitro into an agarose brain tissue model. The electrode-lined sheath will be decorated with eluting neurotrophic factors to promote in vivo neural tissue ingrowth post-implantation. These features will enhance tissue integration and improve recording quality towards realizing reliable chronic neural interfaces.

Graphical abstract: Novel flexible Parylene neural probe with 3D sheath structure for enhancing tissue integration

Article information

Article type
Paper
Submitted
16 Aug 2012
Accepted
22 Oct 2012
First published
16 Nov 2012

Lab Chip, 2013,13, 554-561

Novel flexible Parylene neural probe with 3D sheath structure for enhancing tissue integration

J. T.W. Kuo, B. J. Kim, S. A. Hara, C. D. Lee, C. A. Gutierrez, T. Q. Hoang and E. Meng, Lab Chip, 2013, 13, 554 DOI: 10.1039/C2LC40935F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements