Issue 1, 2012
From the journal:

Lab on a Chip

Ferrofluid mediated nanocytometry†

Ayse Rezzan Kosea  and  Hur Koser*b  

* Corresponding authors

a School of Engineering and Applied Science, Yale University, 15 Prospect St., Becton Center, Room 608, New Haven, USA
E-mail: ayse.kose@yale.edu
Fax: +1 (203) 432-6420
Tel: +1 (203) 432-8573

b School of Engineering and Applied Science, Yale University, 15 Prospect St., Becton Center, Room 507, New Haven, USA
E-mail: hur.koser@yale.edu
Fax: +1 (203) 432-6420
Tel: +1 (203) 432-9629

Abstract

We present a low-cost, flow-through nanocytometer that utilizes a colloidal suspension of non-functionalized magnetic nanoparticles for label-free manipulation and separation of microparticles. Our size-based separation is mediated by angular momentum transfer from magnetically excited ferrofluid particles to microparticles. The nanocytometer is capable of rapidly sorting and focusing two or more species, with up to 99% separation efficiency and a throughput of 3 × 104 particles/s per mm2 of channel cross-section. The device is readily scalable and applicable to live cell sorting with biocompatible ferrofluids, offering competitive cytometer performance in a simple and inexpensive package.

Graphical abstract: Ferrofluid mediated nanocytometry

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Article information

DOI
https://doi.org/10.1039/C1LC20864K
Article type
Paper
Submitted
10 Sep 2011
Accepted
20 Oct 2011
First published
11 Nov 2011

Lab Chip, 2012,12, 190-196

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Ferrofluid mediated nanocytometry

A. R. Kose and H. Koser, Lab Chip, 2012, 12, 190 DOI: 10.1039/C1LC20864K

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