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Issue 18, 2011
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Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network

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Abstract

The network of erythrocyte cytoskeletal proteins significantly influences erythrocyte physical and biological properties. Here we show that the kinetics of erythrocyte lysis during exposure to an electric field is sensitively correlated with defects in the cytoskeletal network. Histograms compiled from single-cell electrical lysis data show characteristics of erythrocyte populations that are deficient in a specific cytoskeletal protein, revealing the presence of cell subpopulations.

Graphical abstract: Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network

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Publication details

The article was received on 01 May 2011, accepted on 06 Jul 2011, published on 25 Jul 2011 and first published online on 25 Jul 2011


Article type: Communication
DOI: 10.1039/C1LC20365G
Citation: Lab Chip, 2011,11, 3053-3056
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    Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network

    N. Bao, G. C. Kodippili, K. M. Giger, V. M. Fowler, P. S. Low and C. Lu, Lab Chip, 2011, 11, 3053
    DOI: 10.1039/C1LC20365G

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