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Issue 19, 2010
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Separation and metrology of nanoparticles by nanofluidic size exclusion

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Abstract

A nanofluidic technology for the on-chip size separation and metrology of nanoparticles is demonstrated. A nanofluidic channel was engineered with a depth profile approximated by a staircase function. Numerous stepped reductions in channel depth were used to separate a bimodal mixture of nanoparticles by nanofluidic size exclusion. Epifluorescence microscopy was used to map the size exclusion positions of individual nanoparticles to corresponding channel depths, enabling measurement of the nanoparticle size distributions and validation of the size separation mechanism.

Graphical abstract: Separation and metrology of nanoparticles by nanofluidic size exclusion

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Publication details

The article was received on 14 May 2010, accepted on 09 Jul 2010 and first published on 11 Aug 2010


Article type: Technical Note
DOI: 10.1039/C0LC00029A
Citation: Lab Chip, 2010,10, 2618-2621
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    Separation and metrology of nanoparticles by nanofluidic size exclusion

    S. M. Stavis, J. Geist and M. Gaitan, Lab Chip, 2010, 10, 2618
    DOI: 10.1039/C0LC00029A

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