Issue 20, 2009
From the journal:

Lab on a Chip

Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst†

Masahiro Sato,*a   Keiichiro Matsushima,b   Hajime Kawanami,*a   Maya Chatterjee,a   Toshiro Yokoyama,a   Yutaka Ikuhsimaa  and  Toshishige Maro Suzukia  

* Corresponding authors

a National Institute of Advanced Industrial Science and Technology (AIST), Research Center for Compact Chemical Process, 4-2-1 Nigatake, Miyagino-ku, Sendai, Japan
E-mail: masahiro-satou@aist.go.jp, h-kawanami @aist.go.jp
Fax: +81-22-237-5224
Tel: +81-22-237-2026

b Hokkaido Industrial Research Institute, Department of Environmental Process Engineering, Kita-ku, Sapporo, Japan

Abstract

A high-speed, highly efficient chemoselective N-acylation by anhydride was achieved in the absence of catalyst for exothermic (ΔH > 0) and endothermic (ΔH < 0) acylation of various amines and anilines with the microreaction system of ambient water (µ-onH2O) and subcritical water (µ-subH2O), where the desired N-acylated products are chemoselectively obtained with high yield(s) and excellent selectivity (>95%).

Graphical abstract: Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst

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Article information

DOI
https://doi.org/10.1039/B913515D
Article type
Communication
Submitted
07 Jul 2009
Accepted
24 Aug 2009
First published
07 Sep 2009

Lab Chip, 2009,9, 2877-2880

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Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst

M. Sato, K. Matsushima, H. Kawanami, M. Chatterjee, T. Yokoyama, Y. Ikuhsima and T. M. Suzuki, Lab Chip, 2009, 9, 2877 DOI: 10.1039/B913515D

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