Jump to main content
Jump to site search

Issue 9, 2009
Previous Article Next Article

A facile “liquid-molding” method to fabricate PDMS microdevices with 3-dimensional channel topography

Author affiliations

Abstract

This work deals with a facile “liquid-molding” technology to fabricate PDMS microdevices with complex structured microchannels, the main procedures of which involves: (1) Photo-lithographically fabricating chemical micropatterns of hydrogels on silanized glass substrates to form heterogeneous hydrophilic/hydrophobic surfaces; (2) Fabricating stable 3D surface relief patterns of a liquid viadip-coating the hydrogel patterned substrate in a polar solution; (3) Fabricating PDMS microfluidic devices via a slightly modified replica molding procedure, using a liquid patterned substrate as the molding template. In addition to its simplicity compared to conventional microfabrication methods, this technology produces microchannels with 3D surface topography, which allows for more flexibility in device design and applications. We discuss the main features of the liquid-molding method as well as the structural characteristics of liquid-molded microchannels. We demonstrate the potential application of these “liquid-molded” PDMS (LM-PDMS) devices by designing a cell trapping microdevice that is capable of trapping multiple or individual cells through simple operation procedures.

Graphical abstract: A facile “liquid-molding” method to fabricate PDMS microdevices with 3-dimensional channel topography

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Oct 2008, accepted on 22 Jan 2009 and first published on 16 Feb 2009


Article type: Paper
DOI: 10.1039/B818721E
Citation: Lab Chip, 2009,9, 1200-1205
  •   Request permissions

    A facile “liquid-molding” method to fabricate PDMS microdevices with 3-dimensional channel topography

    X. Liu, Q. Wang, J. Qin and B. Lin, Lab Chip, 2009, 9, 1200
    DOI: 10.1039/B818721E

Search articles by author

Spotlight

Advertisements