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Issue 5, 2008
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Automated cell culture in high density tubeless microfluidic device arrays

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Abstract

Microfluidics is poised to have an impact on life sciences research. However, current microfluidic methods are not compatible with existing laboratory liquid dispensing and detection infrastructure. This incompatibility is a barrier to adoption of microfluidic systems and calls for improved approaches that will enhance performance and promote acceptance of microfluidic systems in the life sciences. Ease of use, standardized interfaces and automation remain critical challenges. We present a platform based on surface tension effects, where the difference in pressure inside drops of unequal volume drives flow in passive structures. We show integration with existing laboratory infrastructure, microfluidic operations such as pumping, routing and compartmentalization without discrete micro-components as well as cell patterning in both monolayer and three-dimensional cell culture.

Graphical abstract: Automated cell culture in high density tubeless microfluidic device arrays

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Publication details

The article was received on 08 Oct 2007, accepted on 01 Feb 2008 and first published on 20 Mar 2008


Article type: Paper
DOI: 10.1039/B715375A
Citation: Lab Chip, 2008,8, 717-724
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    Automated cell culture in high density tubeless microfluidic device arrays

    I. Meyvantsson, J. W. Warrick, S. Hayes, A. Skoien and D. J. Beebe, Lab Chip, 2008, 8, 717
    DOI: 10.1039/B715375A

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