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Issue 9, 2007
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Planar optofluidic chip for single particle detection, manipulation, and analysis

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Abstract

We present a fully planar integrated optofluidic platform that permits single particle detection, manipulation and analysis on a chip. Liquid-core optical waveguides guide both light and fluids in the same volume. They are integrated with fluidic reservoirs and solid-core optical waveguides to define sub-picoliter excitation volumes and collect the optical signal, resulting in fully planar beam geometries. Single fluorescently labeled liposomes are used to demonstrate the capabilities of the optofluidic chip. Liposome motion is controlled electrically, and fluorescence correlation spectroscopy (FCS) is used to determine concentration and dynamic properties such as diffusion coefficient and velocity. This demonstration of fully planar particle analysis on a semiconductor chip may lead to a new class of planar optofluidics-based instruments.

Graphical abstract: Planar optofluidic chip for single particle detection, manipulation, and analysis

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Publication details

The article was received on 12 Jun 2007, accepted on 13 Jun 2007 and first published on 27 Jun 2007


Article type: Paper
DOI: 10.1039/B708861B
Citation: Lab Chip, 2007,7, 1171-1175
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    Planar optofluidic chip for single particle detection, manipulation, and analysis

    D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins and H. Schmidt, Lab Chip, 2007, 7, 1171
    DOI: 10.1039/B708861B

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