Issue 8, 2006
From the journal:

Lab on a Chip

Initial study of two-phase laminar flow extraction chip for sample preparation for gas chromatography

Hong Xiao,abc   Dong Liang,abc   Guanchao Liu,abc   Min Guo,ce   Wanli Xingabcd  and  Jing Cheng*abcd  

* Corresponding authors

a Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China

b Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing, China

c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Changping District, Beijing, China

d State Key Laboratory for Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing, China
E-mail: jcheng@tsinghua.edu.cn

e CapitalBio Corp., 18 Life Science Parkwary, Changping District, Beijing, China

Abstract

A sample preparation method for gas chromatography using a two-phase, laminar flow extraction PDMS/glass chip has been developed. A stable two-phase laminar interface was obtained by surface modification, and the organic extraction phase and the aqueous sample phase were separated effectively when the two-phase laminar flows exit the chip. Experiments were conducted on the chip to extract ephedrine from aqueous solution. Good reproducibility was obtained over the entire range of ephedrine concentration using the extraction chips (CV range 2.7%–4.5%). Effects of salt and solvent on extraction efficiency were studied.

Graphical abstract: Initial study of two-phase laminar flow extraction chip for sample preparation for gas chromatography

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Article information

DOI
https://doi.org/10.1039/B600374E
Article type
Paper
Submitted
11 Jan 2006
Accepted
17 May 2006
First published
31 May 2006

Lab Chip, 2006,6, 1067-1072

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Initial study of two-phase laminar flow extraction chip for sample preparation for gas chromatography

H. Xiao, D. Liang, G. Liu, M. Guo, W. Xing and J. Cheng, Lab Chip, 2006, 6, 1067 DOI: 10.1039/B600374E

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