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Issue 38, 2012
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Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery

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Abstract

In this contribution, lipid monolayer membrane functionalized graphene sheets were prepared using a facile method. Interactions between the graphene and different types of liposomes, including charged and neutral, were also investigated. We found that the anionic liposomes could spontaneously self-organize into lipid monolayer membranes, partially covering the surface of graphene sheets. The resultant lipid monolayer functionalized graphene nanomaterials exhibited high stability in aqueous solution and an excellent performance as carrier for loading the anticancer drug, doxorubicin (DOX), with a high loading capacity of 70%. The loaded drug can be released under pH control. 10% and 14% of the bound DOX was released after 54 h at pH 10.0 and 7.0, respectively. Whereas, about 70% of DOX was released after 54 h at pH 5.0.

Graphical abstract: Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery

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Publication details

The article was received on 10 Jul 2012, accepted on 16 Aug 2012 and first published on 16 Aug 2012


Article type: Paper
DOI: 10.1039/C2JM34494G
Citation: J. Mater. Chem., 2012,22, 20634-20640
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    Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery

    J. Liu, S. Guo, L. Han, T. Wang, W. Hong, Y. Liu and E. Wang, J. Mater. Chem., 2012, 22, 20634
    DOI: 10.1039/C2JM34494G

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