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Issue 37, 2012
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Electrospinning of in situ crosslinked collagen nanofibers

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Abstract

A simple one-step approach to electrospin Type I collagen in the presence of the chemical crosslinking agents 1-ethyl-3-(3-dimethyl-aminopropyl)-1-carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) has been developed to generate water-insoluble collagen nanofiber scaffolds without the need for post-crosslinking. SEM images indicate that fibrous surface morphology of collagen scaffolds was well retained after the in situ crosslinking process and following water treatment. The resultant collagen demonstrated a similar uniaxial tensile behavior of native tissue in mechanical testing.

Graphical abstract: Electrospinning of in situ crosslinked collagen nanofibers

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Publication details

The article was received on 15 Mar 2012, accepted on 06 Jul 2012 and first published on 09 Jul 2012


Article type: Paper
DOI: 10.1039/C2JM31618H
Citation: J. Mater. Chem., 2012,22, 19412-19417
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    Electrospinning of in situ crosslinked collagen nanofibers

    L. Meng, O. Arnoult, M. Smith and G. E. Wnek, J. Mater. Chem., 2012, 22, 19412
    DOI: 10.1039/C2JM31618H

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