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Issue 12, 2012
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Multifold enhanced T2 relaxation of ZnFe2O4 nanoparticles by jamming them inside chitosan nanospheres

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Abstract

ZnFe2O4 nanoparticles were tightly packed and encapsulated in chitosan nanospheres by a nonsolvent-aided counterion complexation method. The obtained hybrid nanospheres exhibited not only the superparamagnetic properties provided by pure ZnFe2O4 nanoparticles but also a much higher r2 relaxivity value than separate ZnFe2O4 nanoparticles, representing an approximately 3 to 16 fold increase. This was attributed to the high ZnFe2O4 payload and ZnFe2O4 nanoparticle clustering effect in the core of the nanospheres. The MR images generated in vivo demonstrated that the hybrid nanospheres showed an excellent contrast in T2 weighted MRI and a high MRI sensitivity in the tumor sites for both passive and active targeting samples. In addition, the biodistribution analysis revealed that the obtained hybrid nanospheres could accumulate at tumor sites via passive and active targeting strategies.

Graphical abstract: Multifold enhanced T2 relaxation of ZnFe2O4 nanoparticles by jamming them inside chitosan nanospheres

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Publication details

The article was received on 11 Oct 2011, accepted on 11 Jan 2012 and first published on 10 Feb 2012


Article type: Paper
DOI: 10.1039/C2JM15133B
Citation: J. Mater. Chem., 2012,22, 5684-5693
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    Multifold enhanced T2 relaxation of ZnFe2O4 nanoparticles by jamming them inside chitosan nanospheres

    Y. Lin, W. Yao, Y. Cheng, H. Qian, X. Wang, Y. Ding, W. Wu and X. Jiang, J. Mater. Chem., 2012, 22, 5684
    DOI: 10.1039/C2JM15133B

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