Issue 40, 2011

Diopside (CaO·MgO·2SiO2)–fluorapatite (9CaO·3P2O5·CaF2) glass-ceramics: potential materials for bone tissue engineering

Abstract

Glass-ceramics in the diopside (CaMgSi2O6)–fluorapatite [Ca5(PO4)3F] system are potential candidates for restorative dental and bone implant materials. In the present study, a series of glasses along the diopside–fluorapatite binary system have been prepared with varying diopside/fluorapatite ratios for their potential applications in bone tissue engineering. The glasses were obtained from compositions with fluorapatite contents varying between 0 and 40 wt%. The sintering ability and crystallization kinetics of as obtained amorphous glasses have been studied through hot-stage microscopy (HSM) and differential thermal analysis (DTA), respectively, while crystalline phase evolution in sintered GCs has been followed by X-ray diffraction (XRD) adjoined with the Rietveld-R.I.R. technique and scanning electron microscopy (SEM). Further, biodegradation and apatite forming ability of glass-ceramics were investigated by immersion of glass-ceramic discs in simulated body fluid (SBF) solution while chemical degradation and weight loss of glass-ceramics were studied by immersion in Tris–HCl in accordance with the ISO 10993-14 standard. The addition of fluorapatite (10–25 wt%) in the diopside glass system significantly enhanced the sintering ability of glass-ceramics and improved their apatite forming ability along with their biodegradation behaviour. Moreover, the in vitro cellular responses to glass-ceramics showed good cell viability and significant stimulation of osteoblastic differentiation, suggesting the possible use of the glass-ceramics for bone regeneration.

Graphical abstract: Diopside (CaO·MgO·2SiO2)–fluorapatite (9CaO·3P2O5·CaF2) glass-ceramics: potential materials for bone tissue engineering

Article information

Article type
Paper
Submitted
29 Apr 2011
Accepted
18 Aug 2011
First published
13 Sep 2011

J. Mater. Chem., 2011,21, 16247-16256

Diopside (CaO·MgO·2SiO2)–fluorapatite (9CaO·3P2O5·CaF2) glass-ceramics: potential materials for bone tissue engineering

I. Kansal, A. Goel, D. U. Tulyaganov, M. J. Pascual, H. Lee, H. Kim and J. M. F. Ferreira, J. Mater. Chem., 2011, 21, 16247 DOI: 10.1039/C1JM11876E

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