Issue 42, 2011

Multifunctional mesoporous silica nanocomposite nanoparticles for pH controlled drug release and dual modal imaging

Abstract

Multifunctional nanocomposite nanoparticles for simultaneous fluorescence and magnetic resonance (MR) imaging, and pH-sensitive drug release were fabricated by immobilizing pH responsive hydrazone bonds, magnetite nanoparticles and fluorescent dyes in mesoporous silica nanoparticles. pH dependent release of doxorubicin was demonstrated and the nanocomposite nanoparticles show fluorescence emission and MR contrast effect.

Graphical abstract: Multifunctional mesoporous silica nanocomposite nanoparticles for pH controlled drug release and dual modal imaging

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2011
Accepted
01 Jun 2011
First published
24 Jun 2011

J. Mater. Chem., 2011,21, 16869-16872

Multifunctional mesoporous silica nanocomposite nanoparticles for pH controlled drug release and dual modal imaging

J. E. Lee, D. J. Lee, N. Lee, B. H. Kim, S. H. Choi and T. Hyeon, J. Mater. Chem., 2011, 21, 16869 DOI: 10.1039/C1JM11869B

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