Jump to main content
Jump to site search

Issue 29, 2011
Previous Article Next Article

DNA immobilization, delivery and cleavage on solid supports

Author affiliations

Abstract

Progress in bio-molecular chemistry, nanotechnology, and surface engineering resulted in the fabrication of nanoscale bio-systems with advanced functionalities. These systems and the related methodologies offer new perspectives for the development of novel bio-related diagnostic tools and gene and/or photodynamic therapy. A key issue in this context is the design and fabrication of “smart surfaces” able to immobilize functional biomolecules and DNA in particular, which can perform a certain function (e.g. hybridize with the target DNA strand) or be delivered or cleaved under the input of external stimuli (chemical, electrochemical, thermal, photochemical, etc.). This review addresses the above points dealing first with immobilization of DNA on various solid substrates using a bottom-up approach and describing later subsequent transport and/or cleavage of DNA using various routes.

Graphical abstract: DNA immobilization, delivery and cleavage on solid supports

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 13 Dec 2010, accepted on 21 Apr 2011, published on 31 May 2011 and first published online on 31 May 2011


Article type: Feature Article
DOI: 10.1039/C0JM04359A
Citation: J. Mater. Chem., 2011,21, 10602-10618
  •   Request permissions

    DNA immobilization, delivery and cleavage on solid supports

    V. Singh, M. Zharnikov, A. Gulino and T. Gupta, J. Mater. Chem., 2011, 21, 10602
    DOI: 10.1039/C0JM04359A

Search articles by author