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Issue 12, 2011
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Collagen-templated sol–gel fabrication, microstructure, in vitro apatite deposition, and osteoblastic cell MC3T3-E1 compatibility of novel silica nanotube compacts

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Abstract

Silica sol particles were coated on collagen fibrils at room temperature as they were soaked in a Stöber type precursor system, consisting of tetraethoxysilaneethanolwaterammonium hydroxide, with or without CaCl2. Calcination of the fibrils at 600 °C led to silica nanotube compacts of cm size. Transmission electron microscope analysis indicated that they consisted of hollow silica nanotubes, where the shell thickness and roughness increased with the calcium content. The Ca-containing compacts were active to depositing petal-like apatite crystallites when soaked in Kokubo's simulated body fluid. Moreover, they enhanced proliferation and differentiation of osteoblast MC3T3-E1 cells, even produced collagen fibrils.

Graphical abstract: Collagen-templated sol–gel fabrication, microstructure, in vitro apatite deposition, and osteoblastic cell MC3T3-E1 compatibility of novel silica nanotube compacts

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Publication details

The article was received on 08 Nov 2010, accepted on 06 Jan 2011 and first published on 14 Feb 2011


Article type: Paper
DOI: 10.1039/C0JM03823G
Citation: J. Mater. Chem., 2011,21, 4332-4338
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    Collagen-templated sol–gel fabrication, microstructure, in vitro apatite deposition, and osteoblastic cell MC3T3-E1 compatibility of novel silica nanotube compacts

    S. Chen, A. Osaka and N. Hanagata, J. Mater. Chem., 2011, 21, 4332
    DOI: 10.1039/C0JM03823G

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