Issue 42, 2010

Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

Abstract

We report an original strategy to transcribe and to fix the self-assembly of G-quadruplex architectures in self-organized nanohybrids. In the first resolution step the G-quartet is pre-amplified in solution in the presence of metal cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection sol–gel step the G-quadruplex is irreversibly fixed in a siloxane inorganic network. The interface between the guanosine moiety and the heterosiloxane 3 is based on a double reversible covalent iminoboronate connection. This contributes to the high levels of adaptability and correlation in the self-organization of the supramolecular G-quadruplex and the inorganic siloxane systems. Biomimetic-type hybrids can be generated by using this strategy.

Graphical abstract: Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

Supplementary files

Article information

Article type
Paper
Submitted
28 Apr 2010
Accepted
02 Jul 2010
First published
27 Aug 2010

J. Mater. Chem., 2010,20, 9443-9448

Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

S. Mihai, Y. Le Duc, D. Cot and M. Barboiu, J. Mater. Chem., 2010, 20, 9443 DOI: 10.1039/C0JM01248C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements