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Issue 44, 2008
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Temperature-sensitive microcapsules with variable optical signatures based on incorporation of quantum dots into a highly biocompatible hydrogel

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Abstract

Biocompatible fluorescent microcapsules were constructed by incorporating CdSe quantum dots into an ionotropic hydrogel. The hydrogel formulation used has been shown to be highly resistant to chelators present in biological media, and the resulting composite shows no leakage of entrained quantum dots over test periods of up to 4 months. The optical signature of the microcapsules is controlled by incorporating mixtures of quantum dots having different sizes into the composite, such that microcapsule composites exhibit Förster resonance energy transfer (average estimated Förster radius of 77 Å). The resulting microcapsules also display so-called smart behavior, as the optical signature displays a linear dependence on temperature over the 20–45 °C range of interest to biological experiments.

Graphical abstract: Temperature-sensitive microcapsules with variable optical signatures based on incorporation of quantum dots into a highly biocompatible hydrogel

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Publication details

The article was received on 15 Jul 2008, accepted on 16 Aug 2008 and first published on 09 Oct 2008


Article type: Paper
DOI: 10.1039/B811905H
Citation: J. Mater. Chem., 2008,18, 5368-5375
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    Temperature-sensitive microcapsules with variable optical signatures based on incorporation of quantum dots into a highly biocompatible hydrogel

    D. Hardison, H. U. Deepthike, W. Senevirathna, T. Pathirathne and M. Wells, J. Mater. Chem., 2008, 18, 5368
    DOI: 10.1039/B811905H

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